Concepedia

Concept

neonatal pulmonary physiology

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4.6K

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226K

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12.5K

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2.1K

Institutions

Postnatal Lung Transition

1960 - 1972

The neonate lung underwent rapid transition from fluid-filled to air-filled, with emphasis on rapid postnatal alveolar fluid clearance, onset of gas exchange, and reorganization of pulmonary circulation; cord clamping timing modulates ductus arteriosus and pulmonary pressures, shaping shunt behavior. Ventilation research focused on how positive-pressure strategies, and later noninvasive approaches, influence ventilation, gas exchange, and clinical outcomes in respiratory distress. Hyaline membrane disease pathophysiology and reparative remodeling defined early lung injury and subsequent recovery, while hemodynamic interactions in neonatal circulation highlighted how the oxygen environment affects ductus arteriosus, shunting, and pulmonary pressures.

Transition to an aerated neonate lung hinges on rapid postnatal alveolar fluid clearance, onset of gas exchange, and reorganization of pulmonary circulation; cord clamping timing modulates ductal and pulmonary pressures and shunt behavior. [18] [7] [15] [19] [9] [2] [8]

Ventilation modalities and mechanics in the newborn became a central focus: how positive-pressure strategies, and later negative-pressure approaches, influence ventilation, gas exchange, and clinical outcomes in respiratory distress. [6] [13] [8] [18]

Hyaline membrane disease pathophysiology, the hyaline membranes, and reparative phenomena define the early pathophysiology and post-event remodeling in neonates. [12] [1] [11]

Hemodynamics and ductus/arterial pressures in neonatal circulation reveal complex cardiopulmonary interactions during transition, including oxygen environment effects on ductus arteriosus, shunting, and pulmonary pressures. [19] [9] [15] [2] [7] [20]

Ventilation-Inflation Coupling in Neonates

1973 - 1979

Surfactant Era Neonatal Ventilation

1980 - 1986

Surfactant and Nitric Oxide

1987 - 1993

Nitric Oxide Neonatal Pulmonary

1994 - 2002

Neonatal Lung Signaling

2003 - 2009

Hyperoxia-Driven Neonatal Lung Injury

2010 - 2016

Angiogenic Vascular Neonatal Physiology

2017 - 2021