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Postnatal Lung Transition
1960 - 1972
The neonate lung underwent rapid transition from fluid-filled to air-filled, with emphasis on rapid postnatal alveolar fluid clearance, onset of gas exchange, and reorganization of pulmonary circulation; cord clamping timing modulates ductus arteriosus and pulmonary pressures, shaping shunt behavior. Ventilation research focused on how positive-pressure strategies, and later noninvasive approaches, influence ventilation, gas exchange, and clinical outcomes in respiratory distress. Hyaline membrane disease pathophysiology and reparative remodeling defined early lung injury and subsequent recovery, while hemodynamic interactions in neonatal circulation highlighted how the oxygen environment affects ductus arteriosus, shunting, and pulmonary pressures.
• Transition to an aerated neonate lung hinges on rapid postnatal alveolar fluid clearance, onset of gas exchange, and reorganization of pulmonary circulation; cord clamping timing modulates ductal and pulmonary pressures and shunt behavior. [18] [7] [15] [19] [9] [2] [8]
• Ventilation modalities and mechanics in the newborn became a central focus: how positive-pressure strategies, and later negative-pressure approaches, influence ventilation, gas exchange, and clinical outcomes in respiratory distress. [6] [13] [8] [18]
• Hyaline membrane disease pathophysiology, the hyaline membranes, and reparative phenomena define the early pathophysiology and post-event remodeling in neonates. [12] [1] [11]
• Hemodynamics and ductus/arterial pressures in neonatal circulation reveal complex cardiopulmonary interactions during transition, including oxygen environment effects on ductus arteriosus, shunting, and pulmonary pressures. [19] [9] [15] [2] [7] [20]
Popular Keywords
Ventilation-Inflation Coupling in Neonates
1973 - 1979
Surfactant Era Neonatal Ventilation
1980 - 1986
Surfactant and Nitric Oxide
1987 - 1993
Nitric Oxide Neonatal Pulmonary
1994 - 2002
Neonatal Lung Signaling
2003 - 2009
Hyperoxia-Driven Neonatal Lung Injury
2010 - 2016
Angiogenic Vascular Neonatal Physiology
2017 - 2021